论文部分内容阅读
目的:探讨血液灌流联合血液透析治疗尿毒症皮肤瘙痒的疗效。方法:将108例尿毒症皮肤瘙痒患者随机分为治疗组和对照组,治疗组接受血液灌流联合血液透析治疗,对照组接受常规血液透析治疗,放射免疫法测定血清甲状旁腺素(PTH)水平。结果:治疗组患者血PTH从(319.6±274.3)ng·L~(-1)降至(167.5±160.3)ng·L~(-1),皮肤瘙痒症状改善率100%,治疗前后比较差异有统计学意义(P<0.05)。对照组血PTH从(316.8±280.2)ng·L~(-1)升至(318.4±282.3)ng·L~(-1),皮肤瘙痒症状改善率38.0%,治疗前后比较差异无统计学意义(P>0.05)。结论:血液灌流联合血液透析能有效地清除PTH,改善患者的皮肤瘙痒症状。
Objective: To investigate the therapeutic effect of hemoperfusion and hemodialysis on pruritus of uremic skin. Methods: 108 patients with uremic pruritus were randomly divided into treatment group and control group. The treatment group received hemoperfusion and hemodialysis. The control group received routine hemodialysis. The level of serum parathyroid hormone (PTH) was measured by radioimmunoassay. . Results: PTH decreased from (319.6 ± 274.3) ng · L -1 to (167.5 ± 160.3) ng · L -1) in the treatment group, and the pruritus symptom improvement rate was 100% in the treatment group Statistical significance (P <0.05). The PTH of the control group increased from (316.8 ± 280.2) ng · L -1 to (318.4 ± 282.3) ng · L -1, and the pruritus symptom improvement rate was 38.0%. There was no significant difference between before and after treatment (P> 0.05). Conclusion: Hemoperfusion combined with hemodialysis can effectively remove PTH and improve skin pruritus in patients.