目的:观察清胆胶囊对胆色素结石豚鼠胆汁中CRP及黏蛋白含量的影响。方法:应用雄性豚鼠建立胆色素结石模型,观察清胆胶囊对其成石率、胆囊容积、胆汁中黏蛋白及C反应蛋白等指标的影响。结果:清胆胶囊组成石率显著降低(P<0.01),胆囊容积明显减小(P<0.05),胆汁中黏蛋白及C反应蛋白明显降低(P<0.05)。结论:清胆胶囊可降低成石胆汁中黏蛋白、C反应蛋白含量,从而发挥逆转成石胆汁及降低结石成石率的作用。 Objective: To observe the effect of Qing Dan Capsule on the content of CRP and mucin in the bile of guinea pig with biliary pigment stones. Methods: The model of bile pigment stones was established in male guinea pigs. The effects of Qing Dan Capsule on its stone formation rate, gallbladder volume, bile mucin and C-reactive protein were observed. Results: The stone ratio of Qing Dan Capsule decreased significantly (P <0.01), the volume of gallbladder decreased significantly (P <0.05), and the content of Bcl-2 protein and C-reactive protein decreased significantly (P <0.05). Conclusion: Qing Dan Capsule can reduce the content of mucin and C-reactive protein in bile stone, and thus play a role in reversing stone bile and reducing the rate of stone formation.