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目的了解恶性疟原虫对青蒿琥酯的敏感性。方法研制成功青蒿琥酯涂药板和便于现场使用的培养基后,1986—2007年采用世界卫生组织(WHO)推荐的体外微量法,在海南省开展了恶性疟原虫对青蒿琥酯的敏感性监测。结果 1986—2007年共监测了8次,检测237例病人,完全抑制疟原虫裂殖体形成的平均药浓度,乐东县抱由镇由1986年0.028 pmol/μL血升至2002年0.135 pmol/μL血,升高至4.82倍(P<0.01);≥4pmol/μL血完全抑制裂殖体形成例数所占百分比,由1986年的5.5%升至2002年为21.8%,升高至3.96倍(P<0.01)。三亚市雅亮乡的检测结果与乐东县抱由镇2002年的结果基本相似。结论海南省恶性疟原虫对青蒿琥酯敏感性在逐渐下降。
Objective To understand the sensitivity of Plasmodium falciparum to artesunate. Methods After the successful artesunate-coated plates and the medium for field use were successfully developed, from 1986 to 2007, an in vitro micro-assay recommended by the World Health Organization (WHO) was conducted to detect the effects of Plasmodium falciparum on artesunate Sensitivity monitoring. Results During 1986-2007, a total of 8 tests were conducted. A total of 237 patients were tested and the average drug concentration was completely inhibited. The average blood concentration of P. falciparum schistosome was raised from 0. 28 pmol / μL in 1986 to 0.135 pmol / μL blood to 4.82 folds (P <0.01). The percentage of cases with> 4 pmol / μL blood suppressive schizont formation increased from 5.5% in 1986 to 21.8% in 2002, up to 3.96 folds (P <0.01). Ya-Xiang Sanya City, the test results and Ludong Dong-hua by 2002 the town’s results are basically similar. Conclusion The sensitivity of Plasmodium falciparum to artesunate in Hainan Province is gradually decreasing.