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目的探讨瑞芬太尼超前镇痛在乳腺癌根治手术患者中的应用效果。方法选取2012年2月至2015年1月间行择期乳腺根治术的80例乳腺癌患者,采用简单随机化的方法分为实验组和对照组,每组40例。实验组患者术前15 min给予瑞芬太尼,对照组患者给予生理盐水代替,比较两组患者的镇痛效果、术后镇痛药物的使用、心血管反应和不良反应。结果从开始诱导到手术结束后,实验组患者的心率和平均动脉压均明显低于对照组,差异有统计学意义(P<0.05)。实验组患者术后24 h镇痛药用量和不良反应均明显少于对照组,差异有统计学意义(P<0.05)。结论瑞芬太尼超前镇痛应用于乳腺癌根治手术患者,能在很好地控制患者的疼痛的基础上减少止痛药的使用,并且能明显减少手术过程中患者的心血管反应及不良反应,值得临床推广。
Objective To investigate the effect of remifentanil advanced analgesia in patients undergoing radical surgery for breast cancer. Methods Eighty patients with breast cancer undergoing elective radical mastectomy between February 2012 and January 2015 were randomly divided into experimental group and control group with 40 cases in each group. Patients in the experimental group were given remifentanil 15 minutes before operation, and saline was given instead in the control group. The analgesic effect, postoperative analgesic use, cardiovascular response and adverse reactions were compared between the two groups. Results From the beginning of induction to the end of surgery, the heart rate and mean arterial pressure in the experimental group were significantly lower than those in the control group (P <0.05). The amount of analgesic drugs and adverse reactions in experimental group 24 hours after operation were significantly less than those in control group (P <0.05). Conclusion Remifentanil advanced analgesia applied to patients undergoing radical surgery for breast cancer can reduce the use of painkillers on the basis of good patient pain control and can significantly reduce cardiovascular reactions and adverse reactions in patients undergoing surgery. Worth clinical promotion.