目的分析广州市黄埔区手足口病流行病学特征及流行因素,为制定有效的防控措施提供科学依据。方法收集《国家疾病监测信息报告管理系统》及《广州市突发公共卫生事件监测与预警信息系统》中广州市黄埔区2009～2012年手足口病疫情资料,采用描述性流行病学方法进行分析。结果 2009～2012年广州市黄埔区手足口病报告病例7389例,年平均发病率434.39/10万,无死亡病例,报告重症病例2例,重症率为0.03%;发病呈现双峰特点,主高峰为4～7月,次高峰为9～10月;全区各街道均有发病,黄埔街报告病例数最多,共1327例,穗东街发病率最高,为740.41/10万;4年报告病例以5岁以下儿童为主,共7021例,占95.02%,男女性别发病率比为1.15:1,发病以散居儿童和托幼儿童为主;检测251份手足口病病例标本,肠道病毒阳性率70.92%,其中CoxA16阳性率25.90%、EV71阳性率24.30%、其他肠道病毒阳性率19.92%;全区共报告手足口病聚集性疫情199起,主要发生在幼儿园,占88.44%,对73起疫情采样,60起肠道病毒阳性,其中EV71阳性率32.88%,CoxA16阳性率28.77%,CoxA16和EV71同时检出阳性率8.22%。结论 2009～2012年广州市黄埔区手足口病处于高发状态,发病有明显的季节和人群特征,幼儿园是发生聚集性疫情的主要场所;CoxA16和EV71肠道病毒是引起黄埔区手足口病的主要病原体。应加强政府主导,部门合作,在加强手足口病疫情监测和病原监测工作的同时,大力开展宣传教育。 Objective To analyze the epidemiological characteristics and prevalence factors of hand, foot and mouth disease in Huangpu District of Guangzhou City, and provide scientific evidence for effective prevention and control measures. Methods Epidemiological data of hand-foot-mouth disease in 2009 ~ 2012 in Huangpu District of Guangzhou City collected from “National Disease Surveillance Information Reporting Management System” and “Guangzhou Public Health Emergency Monitoring and Early Warning Information System” were analyzed by descriptive epidemiological method . Results 7389 cases of hand-foot-mouth disease were reported in Huangpu District of Guangzhou from 2009 to 2012, with an average annual incidence of 434.39 / 100 000. There were no deaths, 2 cases of severe cases were reported, and the rate of severe cases was 0.03%. The incidence showed bimodal characteristics with main peak From April to July and the next peak was from September to October. The incidence of all streets in the district was high. The number of reported cases in Huangpu Street was the highest, with a total of 1,327 cases, with the highest incidence rate of Guangzhou earning 740.41 / 100,000. Four reported cases A total of 7021 children were under 5 years old, accounting for 95.02%. The incidence rate of male to female was 1.15: 1. The incidence was mainly for scattered children and nursery children; 251 cases of hand, foot and mouth disease were detected, and enterovirus positive Rate was 70.92%, of which CoxA16 positive rate was 25.90%, EV71 positive rate was 24.30%, and other enterovirus positive rate was 19.92%. A total of 199 cases of HFMD were reported in the region, mainly in kindergartens, accounting for 88.44% and 73 Outbreaks were sampled and 60 cases were positive for enterovirus. The positive rate of EV71 was 32.88%, the positive rate of CoxA16 was 28.77%, and the positive rate of CoxA16 and EV71 was 8.22% at the same time. Conclusion Hand-foot-mouth disease in Huangpu district of Guangzhou from 2009 to 2012 was in a high-incidence state with obvious seasonal and crowd-onset characteristics. Kindergarten was the major site for cluster outbreaks. CoxA16 and EV71 enterovirus were the main causes of HFMD in Huangpu District Pathogen. The government-led and departmental cooperation should be strengthened. While strengthening the monitoring and pathogen monitoring of hand, foot and mouth disease epidemics, publicity and education should be vigorously carried out.