We first make use of aminolysis of calix[4]arene esters to synthesize calix[4]arene amides. When the two ethyl esters of the calix[4]arene esters are aminolysized, the 1, 3-amide derivative is formed selectively. The crystal structures of the calix-[4]arene with two butyl amide (3b) and four butyl amide moieties (4b) were determined. The intermolecular hydrogen bonds make 4b form two-dimensional net work insolid state. The 1H NMR spectra prove that 3b is of a pinched cone conformation, while 4b and tetraheptylamide-calix[4]arene (6b) take fast interconversion between two C2v isomers in solution and appear an apparent cone conformation at room temperature. As decreasing temperature, the interconversion rate decreases gradually and, finally, the interconversion process is frozen at Tc = -10℃, which makes both conformations of 4b and 6b the pinched cone structures. The hydrogen bond improves the interconversion barrier, and the large different values of the potential barrier between 6b and 4b (or 6b) may We first make use of aminolysis of calix [4] arene esters to synthesize calix [4] arene amides. When the two ethyl esters of the calix [4] arene esters are aminolysized, the 1, 3-amide derivative is formed selectively. The structures of the calix- [4] arene with two butyl amide (3b) and four butyl amide moieties (4b) were determined. The intermolecular hydrogen bonds make 4b form two-dimensional net work insolid state. The 1H NMR spectra prove that 3b is of a pinched cone conformation, while 4b and tetraheptylamide-calix [4] arene (6b) take fast interconversion between two C2v isomers in solution and appear an apparent cone conformation at room temperature. Ascending temperature, the interconversion rate decreases gradually and, finally, the interconversion process is frozen at Tc = -10 ° C, which makes both conformations of 4b and 6b the pinched cone structures. The hydrogen bond improves the interconversion barrier, and the large different values ​​of the potential barrier between 6b and 4b (or 6b) may