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波叶大黄多糖(Rheum hotaoense polysaccharide,RHP)具有明显的降血脂和抗凝血作用。ig RHP 100,200mg/kg,可分别使蛋黄诱导的高血脂症小鼠血清总胆固醇(TC)降低45%,46%,甘油三酯(TG)降低42%,67%,肝脏TC分别降低63%,65%,TG降低14%,55%,过氧化脂质(MDA)降低49%,66%;对正常小鼠血清TC无明显影响;小鼠给药后30min与对照组相比,血凝时间分别延长93%,110%。小鼠ip给药后10min与对照组相比,血凝时间分别延长101%,116%。ig RHP 45,90mg/kg,可分别使高脂饲料诱导的高脂血症大鼠血清TC降低48%,50%,TG降低30%,31%;肝脏TC降低57%,62%,TG降低23%,30%,MDA降低26%,41%。RHP体外可使凝血时间比生理盐水对照组延长250%,凝血酶原时间延长264%。家兔ig RHP 56mg/kg后白陶土部分凝血活酶时间延长34%。
Rheum hotaoense polysaccharide (RHP) has obvious anti-hyperlipidemic and anticoagulant effects. ig RHP 100 and 200mg / kg respectively reduced the serum total cholesterol (TC) by 45%, 46%, triglyceride (TG) by 42%, 67% and liver TC by 63% , 65%, TG decreased by 14%, 55%, lipid peroxidation (MDA) decreased by 49%, 66%; no significant effect on normal mice serum TC; 30min after administration of the mice compared with the control group, Time were extended 93%, 110%. Compared with the control group, the clotting time was prolonged by 101% and 116%, respectively, 10 minutes after ip administration. ig RHP 45 and 90 mg / kg respectively, the serum TC of rats with hyperlipidemia induced by high-fat diet decreased 48%, 50%, 30%, 31% lower TG respectively; 57%, 62% 23%, 30%, MDA decreased by 26%, 41%. RHP clotting time in vitro can extend the clotting time than the control group of 250%, prothrombin time by 264%. Rabbit ig RHP 56mg / kg after kaolin clay partial thromboplastin time 34%.