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采用改性的Pechini方法在含亚甲基蓝(methylene blue,MB)的二氧化硅颗粒(silica-MB)表面沉积磷酸八钙(octacalcium phosphate,OCP)后制备得到silica-MB@OCP,研究制备工艺条件对载药颗粒的结构、药物释放行为和载体降解性能的影响规律。研究发现聚乙二醇(polyethylene glycol,PEG)的分子量、PEG和柠檬酸的添加量对载药颗粒的物相、化学组成和形貌有显著影响。MB释放量和单体/二聚体的比例随时间的变化规律都对载药颗粒的结构和溶液pH值条件敏感,这与MB分子扩散行为受OCP壳层的结构和溶液条件影响有关。相比于silica-MB,silica-MB@OCP在磷缓冲液和lysosome-like缓冲液中的降解比例要高得多,这是由于M B扩散行为对颗粒结构的破坏产生显著影响导致的。
The modified Pechini method was used to prepare silica-MB @ OCP after the octacalcium phosphate (OCP) was deposited on the surface of silica-MB containing silica blue (MB). The effects of preparation conditions The structure of drug-loaded particles, drug release behavior and carrier degradation of the law. It was found that the molecular weight of polyethylene glycol (PEG), the addition of PEG and citric acid have a significant effect on the phase, chemical composition and morphology of drug-loaded particles. Both the MB release and monomer / dimer ratio change over time are sensitive to the structure of the drug-loaded particles and the pH value of the solution, which is related to the molecular diffusion behavior of MB due to the structure of the OCP shell and the solution conditions. The proportion of silica-MB @ OCP degradation in both phosphate buffer and lysosome-like buffer is much higher than that of silica-MB due to the significant effect of M B diffusion on the breakdown of the granular structure.