系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种常见自身免疫性疾病,常累及皮肤、肾脏、肺脏等全身各器官系统。其发病机制多与免疫耐受功能紊乱有关,但具体机制尚不明确。哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种丝氨酸/苏氨酸蛋白激酶,其信号通路在细胞代谢、生长、增殖及分化等方面起重要作用。近年来已有文献报道mTOR信号通路参与SLE发病机制中的免疫细胞分化、自噬、炎性细胞因子分泌、氧化应激等过程。因此,进一步阐明mTOR信号通路在SLE发病中的作用,对其诊断及靶向治疗具有重要意义。本文就近期mTOR信号通路在SLE中的研究进展作一综述讨论。 Systemic lupus erythematosus (SLE) is a common autoimmune disease, often involving the body, body and organs of the skin, kidneys, lungs and other organs. Its pathogenesis and immunotolerance disorders, but the specific mechanism is not yet clear. Mammalian mammalian target of rapamycin (mTOR) is a serine / threonine protein kinase whose signaling pathway plays an important role in cell metabolism, growth, proliferation and differentiation. In recent years, mTOR signaling pathway has been reported in the pathogenesis of SLE pathogenesis of immune cell differentiation, autophagy, inflammatory cytokine secretion, oxidative stress and other processes. Therefore, to further elucidate the role of mTOR signaling in the pathogenesis of SLE, its diagnosis and targeted therapy is of great significance. This review summarizes the recent progress of mTOR signaling pathway in SLE.