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目的 研究术前选择性动脉灌注化疗对大肠癌的治疗作用。方法 应用氟尿嘧啶、表阿霉素和丝裂霉素对 6 3例大肠癌病人术前进行选择性动脉插管化疗 ,并对其临床表现及病理结果进行了观察和对比。结果 (1)化疗后腹痛减轻有 18例 ,腹胀缓解 16例 ,便血减轻 7例 ,在 13例伴不全梗阻的患者中 ,有 9例缓解 ;(2 )化疗后病理变化有癌细胞出现核固缩、核碎裂、细胞浆凝固、坏死 ,细胞间质出现炎性细胞浸润、水肿、纤维增生 ,血管出现内膜增生和血栓形成 ,这些变化多以中度改变为主 ;而细胞浆坏死及血管内膜增生则呈重度改变。结论 术前选择性动脉灌注化疗可以控制原发灶及微小转移灶 ,缓解梗阻、便血等临床症状 ,从而有利于手术及改善术后生存率
Objective To study the therapeutic effect of preoperative selective arterial infusion chemotherapy on colorectal cancer. Methods Sixty-three cases of patients with colorectal cancer undergoing selective arterial catheterization chemotherapy were treated with fluorouracil, epirubicin and mitomycin. The clinical manifestations and pathological results were observed and compared. Results (1) There were 18 cases of abdominal pain relief after chemotherapy, 16 cases of abdominal distension relief and 7 cases of reduction of blood in the stool. Among 13 cases with incomplete obstruction, 9 cases were relieved. (2) Shrinkage, nuclear fragmentation, cytoplasm coagulation, necrosis, interstitial inflammatory cell infiltration, edema, fibrosis, blood vessels appear intimal hyperplasia and thrombosis, these changes are mostly moderate changes; and cytoplasmic necrosis and Intimal hyperplasia was a significant change. Conclusion Preoperative selective arterial infusion chemotherapy can control the primary tumor and micrometastases, relieve the clinical symptoms such as obstruction and blood in the stool, which is beneficial to the operation and to improve the postoperative survival rate