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目的观察依达拉奉联合叶酸治疗急性脑梗死患者的疗效,及其对机体血清一氧化氮(NO)、丙二醛(MAD)和超氧化物歧化酶(SOD)的影响。方法选择2013年1月至2014年3月在上海市浦东医院住院的脑梗死患者380例,随机分为观察组和对照组,每组190例,对照组予以叶酸治疗,观察组在对照组的基础上予以依达拉奉治疗。比较两组的疗效,分析两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、日常生活活动能力(ADL)评分,以及NO、SOD和MDA水平的变化。结果观察组总有效率为92.00%,对照组总有效为72.00%,观察组的疗效明显优于对照组,差异有统计学意义(χ2=24.520,P<0.01)。治疗后两组的NIHSS评分、NO和MDA水平比治疗前明显降低(P<0.01),且观察组的降低水平更为明显(P<0.01)。ADL评分和SOD水平比治疗前明显升高(P<0.01),观察组的升高水平比对照组更为明显(P<0.01)。结论依达拉奉联合叶酸治疗急性脑梗死有利于清除机体氧自由基,保护脑细胞,从而提高疗效,改善患者的生活质量。
Objective To observe the curative effect of edaravone and folic acid on patients with acute cerebral infarction and its effect on serum nitric oxide (NO), malondialdehyde (MAD) and superoxide dismutase (SOD). Methods 380 patients with cerebral infarction hospitalized in Shanghai Pudong Hospital from January 2013 to March 2014 were randomly divided into observation group and control group, with 190 cases in each group. The control group was treated with folic acid, and the observation group in the control group Based on the edaravone treatment. The curative effect of the two groups was compared. NIHSS score, daily living activity (ADL) score, and the changes of NO, SOD and MDA before and after treatment were analyzed. Results The total effective rate was 92.00% in the observation group and 72.00% in the control group. The curative effect of the observation group was obviously better than that of the control group (χ2 = 24.520, P <0.01). The NIHSS scores, NO and MDA levels in both groups were significantly lower than those before treatment (P <0.01), and the levels of NIHSS in the two groups were more obvious (P <0.01). The ADL score and SOD level were significantly higher than those before treatment (P <0.01), and the level of the observation group was more obvious than that of the control group (P <0.01). Conclusion Edaravone combined with folic acid treatment of acute cerebral infarction is conducive to the removal of oxygen free radicals, protect brain cells, thereby enhancing the efficacy and improve the quality of life of patients.