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新生期小鼠sc谷氨酸单钠(MSG)后能使下丘脑弓状核及其它脑室周围结构神经元坏死。预注吗啡可明显增强MSG的神经毒性作用,使弓状核的神经元坏死数增加。新生期小鼠sc MSG或吗啡+MSG均能破坏动物成年后Y型迷宫分辨学习能力,但对分辨学习的保持(retention)无影响。吗啡+MSG还使动物被动回避反应的保持及脑Ca~(2+)水平明显下降。纳洛酮能逆转吗啡的增强效应。吗啡+MSG引起的脑损伤、学习记忆缺陷(deficiency)及脑Ca~(2+)水平下降三者之间具有明显的平行关系。
Neonatal mouse sc glutamate monosodium (MSG) can make the hypothalamic arcuate nucleus and other periventricular neurons necrosis. Pre-injection of morphine can significantly enhance the neurotoxic effect of MSG, so that arcuate nucleus increased the number of neuronal necrosis. Neonatal mouse sc MSG or morphine + MSG can destroy the ability of adult Y-shaped maze to distinguish learning, but has no effect on the retention of discriminative learning. Morphine + MSG also reduced the level of Ca 2+ in the brain and maintained the passive avoidance reaction. Naloxone reverses the potentiation of morphine. Morphine + MSG induced brain injury, learning and memory deficit (deficiency) and brain Ca ~ (2+) levels decreased significantly in parallel between the three.