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目的:探讨芪丹天胶囊对血小板聚集功能的影响及作用机理。方法:以老年雄性大鼠为血瘀模型,采用血小板聚集法和放免法观察芪丹天胶囊对血小板聚集功能及血浆TXB2、6-keto-PGF1a含量的影响。结果:芪丹天胶囊能明显抑制ADP诱导的血小板聚集,降低血浆中TXB2的含量及TXB2/6-keto-PGF1a的比值。结论:芪丹天胶囊具有良好的抑制血小板聚集作用,其作用机理与降低TXB2有关。
Objective: To investigate the effect of Qidantian capsule on platelet aggregation and its mechanism of action. Methods: The aged male rats were used as blood stasis models. Platelet aggregation and radioimmunoassay were used to observe the effect of Qidantian capsule on the platelet aggregation function and plasma TXB2, 6-keto-PGF1a content. RESULTS: Qidantian capsule could significantly inhibit platelet aggregation induced by ADP, decrease the content of TXB2 in plasma and the ratio of TXB2/6-keto-PGF1a. Conclusion: Qidantian capsule has a good effect of inhibiting platelet aggregation, and its mechanism is related to the reduction of TXB2.