1911年Meisenheimer成功地拆分了第一个手征性磷化合物——甲基乙基苯基氧化膦。其后40多年,磷化合物的拆分多数未能成功。近十几年来,随着新拆分剂的使用、拆分方法的简化,以及磷的立体化学知识的积累,使主要的几类含手征性磷原子的磷化合物,包括生物活性物质都得到了合成和拆分。近年来关于有机磷立体化学的综述评论及专著也都已出版。用手征性叔膦作配位体和过渡金属所组成的催化剂,在不对称均相催化氢化反应中,近来取得了很大的进展。用这类催化剂来合成α-氨基酸,不但可以得到极高旋光纯度的产物,而且可以得到L-或D-两种异构体,这是生化方法或从天然产物都无法得到的。这方面的第一个工业 In 1911 Meisenheimer successfully split the first chiral phosphorus compounds - methyl ethyl phenyl phosphine oxide. Over the next 40 years, the majority of phosphorus compounds were unsuccessful. In recent decades, with the use of new resolving agents, the simplification of the resolution method, and the accumulation of three-dimensional chemical knowledge of phosphorus, the major classes of phosphorus compounds containing chiral phosphorus atoms, including bioactive substances, have been obtained Synthesis and resolution. Recent reviews and monographs on organic phosphorus stereochemistry have also been published. The use of chiral tertiary phosphine as ligand and transition metal catalyst composed of asymmetric homogeneous catalytic hydrogenation has made great progress recently. Synthesis of α-amino acids with these catalysts not only yields products of very high optical purity, but also provides both L- and D- isomers, either biochemically or not from natural products. The first industry in this area