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目的:观察并比较不同制备工艺桃花止泻冲剂的抗腹泻作用。方法:分别用番泻叶、蓖麻油、大黄建立小鼠、大鼠腹泻模型,观察不同工艺制备的桃花止泻冲剂对腹泻动物稀便率的影响。结果:桃花止泻冲剂原剂型和微粉剂可减少番泻叶、蓖麻油和大黄诱导的小鼠、大鼠稀便率和稀便点数。相同剂量下,微粉剂型作用优于原剂型。结论:桃花止泻冲剂微粉剂具有良好的抗腹泻作用,效果优于桃花止泻冲剂原制剂。
Objective: To observe and compare the anti-diarrhea effects of different preparations of Taohua Zhixie Granules. Methods: The diarrhea models of mice and rats were established with senna leaf, castor oil and rhubarb respectively. The effects of different methods on the sparse stool rate of diarrhea animals were observed. Results: The original formulation and powder of Taohua Zhixie granules can reduce the diarrhea, castor oil and rhubarb induced mouse and rat sparse stool rate and the number of loose stools. At the same dosage, the effect of the micropowder dosage form is better than that of the original dosage form. Conclusion: Taohua Zhixie Granule Powder has good anti-diarrhea effect, and its effect is better than that of the original formulation of Taohua Zhixie Granules.