从番荔枝内生真菌Periconia sp.F-31的次生代谢产物中分离得到3个新化合物,通过多种波谱学方法及计算ECD鉴定了所分离化合物的结构,分别为二氯取代的异香豆素pericochlorosin A (1)、含氯取代苯酚化合物pericochlorosin B (2)和十氢化萘衍生物pericoannosin G (3).药理活性评价表明,化合物2具有较强的抗HIV活性,其IC50为2.2μM.“,”Three new compounds (1-3),including a chlorine-containing dihydroisocoumarin pericochlorosin A (1),a chlorinated phenol pericochlorosin B (2) and a decalin derivative pericoannosin G (3),were isolated from endophytic fungus Periconia sp.F-31 of the medicinal plant Annona muricata.The structures and absolute configurations were elucidated by extensive spectroscopic methods and calculated electronic circular dichroism analysis.Compound 2 displayed potent anti-HIV activity with IC50 value of 2.2 μM.