噻嗪类利尿剂治疗高血压无论是在降压还是在降低心脑血管疾病发病率方面的作用均毋庸置疑,作为高血压治疗中的一线药物,亦是联合用药中最常用的药物,其价格低廉,特别适用于轻至中度高血压患者、老年性单纯收缩期高血压治疗。本文通过对此类药物上市后及近十多年来的临床应用进行分析研究,分别就该类药物对血钾、血尿酸、脂代谢、糖代谢的影响进行分析阐述,认为低剂量应用、与其他降压药物联用可以大大减少其对代谢的影响。 Thiazide diuretics in the treatment of hypertension whether in the antihypertensive or in reducing the incidence of cardiovascular and cerebrovascular disease are no doubts, as a first-line treatment of hypertension in the drug is also the most commonly used drugs, the price Low, especially for mild to moderate hypertension in elderly patients with isolated systolic hypertension. In this paper, after the listing of these drugs and the clinical application of the past decade to analyze and study the effects of such drugs on serum potassium, serum uric acid, lipid metabolism, glucose metabolism were analyzed elaborated that low-dose applications, and Other antihypertensive drugs can greatly reduce its impact on metabolism.