消炎痛的药物动力学在人体虽已大量研究,但同时测定其在体内主要的、无活性代谢物——O-去甲基消炎痛,迄未见报道。本文研究了16例中度、退变性类风湿患者(6男,10女)消炎痛新缓释剂型(含药75 mg 胶囊)的血药浓度变化。以气相层析法(电子捕获检测器)测定消炎痛及O-去甲基消炎痛。结果显示,在下午8点(20点)给药后,血浓度无明显高峰出现,曲线比较平 Indomethacin pharmacokinetics in the human body has been a large number of studies, but at the same time its main in the body, inactive metabolites - O-demethyl indomethacin, has not been reported. In this paper, 16 patients with moderate, degenerative rheumatoid patients (6 males and 10 females) indomethacin new sustained-release dosage forms (containing 75 mg capsules) blood drug concentration changes. Indomethacin and O-demethyl indomethacin were determined by gas chromatography (electron capture detector). The results showed that there was no obvious peak of blood concentration after 8:00 (20:00) administration, the curve was flat