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目的探讨肝动脉化疗栓塞术对肝癌患者甲胎蛋白(AFP)的影响及对预后判断的意义。方法通过双抗体夹心两步法对96例肝癌患者治疗前1周内、治疗后3~4周及治疗后7~8周的血清进行AFP测定。结果患者术前血清AFP值为(800.52±190.34)ng/ml,术后3~4周AFP值为(656.02±313.19)ng/ml,与术前比较稍有下降,但差异无统计学意义(P=0.118);术后7~8周AFP值为(324.68±104.36)ng/ml,与术前比较有明显下降(P<0.05)。患者术后随访平均存活时间250 d,最短术后生存时间34 d。结论 AFP作为经导管肝动脉化疗栓塞术术后评定疗效的中长期指标比作为术后3~4周短期观察指标更合适。
Objective To investigate the effect of transcatheter arterial chemoembolization on AFP in patients with liver cancer and its prognostic significance. Methods AFP was measured in 96 patients with hepatocellular carcinoma within 1 week before treatment, 3 to 4 weeks after treatment and 7 to 8 weeks after treatment by double-antibody sandwich two-step method. Results The preoperative serum AFP value was (800.52 ± 190.34) ng / ml and the AFP value at 3 ~ 4 weeks after operation was (656.02 ± 313.19) ng / ml, which was slightly lower than that before operation, but the difference was not statistically significant P = 0.118). The AFP value at 7-8 weeks postoperatively was (324.68 ± 104.36) ng / ml, which was significantly lower than that before operation (P <0.05). The patients were followed up for a mean of 250 days and the shortest postoperative survival time was 34 days. Conclusions The long-term and long-term indexes of the efficacy of AFP as the transcatheter arterial chemoembolization are more suitable than the short-term observation indexes of 3 to 4 weeks postoperatively.