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目的研究多种肿瘤标志物蛋白芯片检测系统(C-12芯片)在肺癌诊断中的临床意义。方法对213例肺癌患者、71例肺良性疾病患者和50例健康体检者的血清肿瘤标志物检测结果及临床资料进行回顾性研究。结果肺癌组的C-12芯片阳性率显著高于肺良性疾病组和健康对照组(64.32%、28.17%、20.00%)。肺癌组与与肺良性疾病组比较,仅CEA、CA242、CAl25阳性率存在显著性差异(P<0.05),其他各项肿瘤标志物3组间差异无统计学意义(P>0.05),肺腺癌、鳞癌均以CEA、CAl25、Ferritin阳性率最高;小细胞肺癌以NSE、CA125阳性率最高。CEA、CAl25阳性率在肺腺癌组明显高于肺鳞癌组。1项以上阳性检测肺癌的敏感性和特异性分别为64.32%和71.83%,2项以上阳性为31.92%和88.73%,3项以上阳性为21.60%和94.37%,四项以上阳性为10.80%和98.59%。CEA、CAl25水平与肺癌临床分期有一定关系。结论蛋白芯片检测系统检测血清肿瘤标志物方法对肺癌诊断的阳性率较高,随着观察指标的增多虽然敏感性下降,但特异性升高,对于初步判断病灶的恶性性质有一定的帮助。有助于肺癌的诊断、组织分型及判定病情进展程度。
Objective To study the clinical significance of multiple tumor marker protein chip detection system (C-12 chip) in the diagnosis of lung cancer. Methods Totally 213 patients with lung cancer, 71 patients with benign lung disease and 50 healthy subjects were retrospectively studied on serum tumor markers and clinical data. Results The positive rate of C-12 chip in lung cancer group was significantly higher than that in benign lung disease group and healthy control group (64.32%, 28.17%, 20.00%). The positive rates of CEA, CA242 and CAl25 in lung cancer group were significantly different from those in benign lung disease group (P <0.05). There was no significant difference among the other three tumor markers (P> 0.05) The positive rates of CEA, CA125 and Ferritin were the highest in both cancer and squamous cell carcinoma. The positive rates of NSE and CA125 were the highest in small cell lung cancer. The positive rates of CEA and CA125 in lung adenocarcinoma group were significantly higher than those in lung squamous cell carcinoma group. The sensitivities and specificities of more than one positive test for lung cancer were 64.32% and 71.83% respectively, with two or more positives being 31.92% and 88.73%, three or more positives being 21.60% and 94.37%, four or more positives being 10.80% and 98.59%. CEA, CAl25 levels and clinical stage of lung cancer have a certain relationship. Conclusions The detection rate of serum tumor markers by protein chip detection system is high in the diagnosis of lung cancer. With the increase of the observation index, the sensitivity is decreased, but the specificity is higher, which is helpful for the preliminary judgment of the malignant nature of the lesion. Help diagnosis of lung cancer, tissue typing and determine the progress of the disease.