Treating weld toes properly can improve the fatigue performance. Ultrasonic impact treatment (UIT) is a more effective and convenient method to enhance the fatigue strength of welded joints and suchlike structures. Fatigue tests were conducted on the specimens made of X65 pipeline steel. The test specimens were investigated on the fatigue strength and the fatigue life at the same stress range level by comparing the ones peened by UIT with the others without the treatment: the fatigue strength of the specimens as UIT, 90% of the fatigue strength of the base mental, is increased by 38% compared with that of as welded only; the fatigue life of the ones as UIT is prolonged by 11 multiples of the ones as welded only.