环孢菌素(CsA)血药浓度治疗范围很窄,且有很大的个体差异,故有必要采取血药浓度监测。临床通常将给药后12～24 h的血药浓度作为监测对象,测出血浓谷值并以此作为调整用药剂量的依据。作者研究了血药浓度监测取样时间与药动学参数之间的关系,希望通过这一途径找出最为合理的取样时间。 Cyclosporine (CsA) blood concentration treatment is very narrow range, and there is a large individual differences, it is necessary to take blood drug concentration monitoring. Clinical drug concentration is usually 12 to 24 h after administration as a monitoring object, blood concentration measured as a valley and as a basis for adjusting the dosage. The authors studied the relationship between the sampling time of plasma concentration monitoring and the pharmacokinetic parameters and hoped to find the most reasonable sampling time by this route.