Quasi-isotropic laminates have isotropic elastic properties in all in-plane directions.Therefore, this kind of laminate is widely used for structural elements. The simpleststacking sequence of quasi-isotropic laminates is [0/-60/60]s. When the direction ofapplied axial load to [0/-60/60]s laminate is inclined at a 30-degree angle, we havethe other quasi-isotropic laminate [30/-30/90]s under axial load. The failure mecha-nisms of these two laminates are, however, entirely different from each other becausethese two laminates have different distribution of the interlaminar stresses. It wasconfirmed by tensile fatigue tests that the [0/-60/60]s laminate does not show any vis-ible fatigue damage, but the [30/-30/90]s laminate develops edge-delamination duringcyclic loading. The analytical results were in good agreement with the experimental results.