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吸烟、饮酒是口咽癌已知的常见病因。近年来,宫颈癌病因学研究取得了突破性进展,证实了高危型的人乳头瘤病毒(HPV)感染是宫颈癌发生的必要条件。新近的研究表明,感染有转录活性的HPV的头颈癌,其基因表达谱完全不同于没有感染HPV的肿瘤,表明HPV感染在头颈鳞癌的形成过程中发挥了重要的作用。本文就口腔HPV感染与口咽癌发生的相关性及临床意义予以综述。1 HPV的生物学特征人乳头瘤病毒(HPV)为乳多空泡病毒科,乳头
Smoking, drinking is a common cause known for oropharyngeal cancer. In recent years, etiology of cervical cancer has made breakthrough research, confirmed that high-risk type of human papillomavirus (HPV) infection is a necessary condition for cervical cancer. Recent studies have shown that the gene expression profile of head and neck cancers infected with transcriptional activity is completely different from that of non-HPV infected tumors, indicating that HPV infection plays an important role in the formation of head and neck squamous cell carcinomas. This article reviews the relationship between oral HPV infection and the occurrence of oropharyngeal carcinoma and its clinical significance. 1 biological characteristics of HPV Human papillomavirus (HPV) is papovavirus, nipple