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目的:通过血栓弹力图(TEG)及常规凝血结果的检测,研究正常妊娠妇女在不同孕期的凝血状态。方法:随机选取200例正常妊娠妇女(早孕63例、中孕58例、晚孕79例)和100例健康非妊娠女性(对照组),分别进行TEG、常规凝血指标(APTT、PT、TT、FIB、FDP、D-D)和血小板(PLT)检测,并对检测的结果进行统计学分析。结果:1TEG指标中,与非妊娠组相比,妊娠组的R、K值明显降低,α角、MA值及CI数明显升高,差异有统计学意义(P<0.05);常规凝血指标中,与非妊娠组相比,妊娠组的PT、TT值明显降低,APTT、FIB、FDP及DD值明显升高,差异有统计学意义(P<0.05)。2R值:中、晚孕组较早孕组明显降低(P<0.05);K值:晚孕组较早孕组明显降低(P<0.05);α角:晚孕组较早孕组明显增高(P<0.05);MA值:妊娠组各时期无显著变化;CI值:中、晚孕组较早孕组明显增高(P<0.05);结论:妊娠期妇女与非妊娠妇女在TEG和常规凝血指标上均存在显著差异,TEG指标中的R值、K值、α角以及CI值在不同的妊娠时期亦存在显著差异。
Objective: To study the coagulation state of normal pregnant women in different stages of pregnancy by detecting the TEG and routine coagulation results. Methods: A total of 200 normal pregnant women (63 cases of early pregnancy, 58 cases of middle pregnancy and 79 cases of late pregnancy) and 100 healthy nonpregnant women (control group) were randomly selected. TEG, routine coagulation indexes (APTT, PT, TT, FIB, FDP, DD) and platelet (PLT) test, and the results of the test for statistical analysis. Results: Compared with non-pregnant group, the values of R and K, the α-angle, the MA value and the CI of 1TEG group were significantly higher than those of non-pregnant group (P <0.05) Compared with non-pregnancy group, the PT and TT values in pregnancy group were significantly decreased, and APTT, FIB, FDP and DD values were significantly increased (P <0.05). (P <0.05); K value: the late pregnancy group was significantly lower than the early pregnancy group (P <0.05); α angle: the late pregnancy group than the early pregnancy group was significantly increased (P < 0.05); MA value: there was no significant change in pregnancy group; CI value: middle and late pregnancy group was significantly higher than the early pregnancy group (P <0.05); Conclusion: Pregnancy and non-pregnant women in TEG and routine coagulation indicators There are significant differences, TEG index in the R value, K value, α angle and CI values in different pregnancy also exist significant differences.