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目的:探讨碱性成纤维细胞生长因子(bFGF)在鼻咽癌组织中表达及其与鼻咽癌浸润转移的关系。方法:采用SP免疫组化法,检测127例鼻咽癌标本和60例鼻咽黏膜慢性炎症组织中bFGF的表达。结果:鼻咽癌组bFGF阳性表达率为78.0%,鼻咽黏膜慢性炎症组无阳性表达,两组比较差异有统计学意义,P<0.05;远处转移组bFGF阳性表达率为89.7%,显著高于无远处转移组的72.7%,两组比较差异有统计学意义,P<0.05。结论:bFGF在鼻咽癌组织中有高表达,参与了鼻咽癌发生发展、浸润转移等生物学行为。bFGF可以作为评价鼻咽癌恶性程度的1个新型指标,来预测鼻咽癌的侵袭转移情况及患者的预后。
Objective: To investigate the expression of basic fibroblast growth factor (bFGF) in nasopharyngeal carcinoma (NPC) and its relationship with infiltration and metastasis of nasopharyngeal carcinoma. Methods: SP immunohistochemical method was used to detect the expression of bFGF in 127 nasopharyngeal carcinoma specimens and 60 chronic nasopharyngeal mucosal inflammatory tissues. Results: The positive expression rate of bFGF in nasopharyngeal carcinoma was 78.0%, but there was no positive expression in chronic inflammation of nasopharyngeal mucosa, the difference was statistically significant (P <0.05). The positive rate of bFGF in distant metastasis was 89.7% Which was higher than 72.7% without distant metastasis group, the difference between the two groups was statistically significant, P <0.05. Conclusion: bFGF is highly expressed in nasopharyngeal carcinoma and is involved in the biological behavior of nasopharyngeal carcinoma, such as invasion and metastasis. bFGF can be used as a new index to evaluate the malignant degree of nasopharyngeal carcinoma to predict the invasion and metastasis of nasopharyngeal carcinoma and the prognosis of patients.