论文部分内容阅读
目的探讨在终止利司培酮治疗后,影响孤独症患儿行为问题复发的因素。方法 37例患儿均为2006年3月-2009年10月在本中心接受康复训练,且因行为问题接受利司培酮口服液治疗达8周以上的孤独症患儿。行为问题得到改善后停药,观察患儿在停药6个月内的攻击、自伤、多动及激惹等症状的复发情况,分析孤独症患儿用药前孤独症行为评定量表(ABC)评分、总服药时间、减量时的剂量及总减量时间等因素对复发的影响。结果 37例患儿均随访6个月,在终止利司培酮治疗6个月内,行为问题复发率为27.02%(10/37例),而用药前ABC评分(Wald=1.107,P=0.293)和减量时的剂量(Wald=2.816,P=0.093)二因素对复发无影响,总服药时间(Wald=4.154,P=0.042,OR=0.874)和总减量时间(Wald=4.089,P=0.043,OR=0.726)则对复发有显著影响。结论利司培酮用药时间越长,减量速度越慢,终止治疗后孤独症患儿行为问题复发的概率就越低。
Objective To explore the factors influencing the recurrence of behavior problems in children with autism after termination of risperidone treatment. Methods Thirty-seven children were autistic children who received rehabilitation training at our center from March 2006 to October 2009 and were treated with risperidone oral solution for more than 8 weeks due to behavioral problems. Behavioral problems improved after discontinuation, observation of children in the withdrawal within 6 months of attack, self-injury, hyperactivity and irritation and other symptoms of recurrence, autistic children with autism before behavioral assessment questionnaire (ABC ) Score, the total medication time, dose reduction and total weight loss time and other factors on the recurrence. Results All 37 children were followed up for 6 months. The recurrence rate of behavioral problems was 27.02% (10/37) in the 6 months after the termination of risperidone, while the ABC score before treatment (Wald = 1.107, P = 0.293 (Wald = 4.154, P = 0.042, OR = 0.874) and total weight loss time (Wald = 4.089, P = 0.043, OR = 0.726) had a significant effect on relapse. Conclusions The longer the risperidone treatment time, the slower the reduction rate, the lower the probability of recurrence of behavior problems in children with autism after termination of treatment.