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目的 探讨利用声学密度 (AD)定量技术早期评价急性心肌梗死 (AMI)患者行直接经皮冠状动脉腔内成形术 (PTCA)的手术疗效。方法 将 4 0例AMI患者分为两组 :18例病人行直接PTCA治疗 (A组 ) ,2 2例病人用药物治疗 (B组 ) ,比较两组病人在入院第 7天时常规超声心动图检查和用AD技术检测的结果。结果 两组病人常规超声心动图各项检查结果比较差别无显著性 (P >0 0 5 )。AD定量检测结果 :A组的背向散射积分周期变化幅度 (CVIB) (4 2± 1 3)dB明显高于B组 (2 5± 2 4 )dB(P <0 0 1) ;A组校正的周期变化延迟时间 (N Delay) 1 0 9± 0 0 8明显低于B组 1 31± 0 16 (P <0 0 1) ;两组间背向散射积分 (IBS)差异无显著性 (P >0 0 5 )。结论 AD技术能够早期反映AMI再灌注心肌的组织学特征 ,为早期评价介入治疗效果、预测心功能改善情况、判定心肌活性提供了一种新的技术手段。
Objective To evaluate the clinical efficacy of direct percutaneous transluminal coronary angioplasty (PTCA) in the early assessment of acute myocardial infarction (AMI) using acoustic densitometry (AD) quantitative techniques. Methods Forty patients with AMI were divided into two groups: 18 patients received direct PTCA (group A) and 22 patients received drug therapy (group B). The echocardiography was performed on the 7th day after admission And using AD technology to test the results. Results There was no significant difference between the two groups in routine echocardiography (P> 0.05). The result of quantitative detection of AD showed that the CVB (4 2 ± 1 3) dB of group A was significantly higher than that of group B (25 ± 2 4) dB (P <0.01) (N Delay) 1 0 9 ± 0 0 8 was significantly lower than that of group B 1 31 ± 0 16 (P 0 01). There was no significant difference in backscatter integral (IBS) between the two groups (P > 0 0 5). Conclusion The AD technique can early reflect the histological characteristics of AMI myocardial reperfusion, which provides a new technical means for early evaluation of interventional therapy, prediction of cardiac function improvement and determination of myocardial activity.