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作者报告1例80岁溃疡性食管炎的妇女,应用甲腈咪胍(cimetidine)300mg每日4次和抗酸药治疗。治前血尿素氮20mg％、肌酐1.5mg％。用药后2周开始感觉疲乏并渐加重,无发热、皮疹和关节痛,用药后4周入院检查,血压160/75mmHg,血白细胞12,200/mm~3,嗜酸性7％,尿比重为1.017,白细胞5～7/高倍,24小时尿蛋白定量为800mg,尿培养阴性,血尿素氮28mg％、肌酐2.5mg％。入院第8天血尿素氮和肌酐分别升至40和4.1mg％,遂停用甲腈咪胍但抗酸药继续用;第9天开始加用强的松每天60mg;第10天行肾活检,光镜下见肾间质有明显的淋巴细胞和浆细胞浸润。免疫荧光检查:在肾小
The authors report a 80-year-old woman with ulcerative esophagitis who was treated with 300 mg cimetidine 4 times daily and antacid. Pre-treatment blood urea nitrogen 20mg%, creatinine 1.5mg%. Two weeks after treatment, the patients began to feel tired and gradually increased, without fever, rashes and joint pain. The patients were admitted to the hospital for 4 weeks after treatment. The blood pressure was 160/75 mmHg, blood leukocyte 12,200 / mm 3, eosinophilicity 7% and urine specific gravity 1.017. 5 ~ 7 / high, 24-hour urine protein was 800mg, urine culture negative, blood urea nitrogen 28mg%, creatinine 2.5mg%. Blood urea nitrogen and creatinine rose to 40 and 4.1 mg% respectively on the 8th day after admission. Then, nitidinemidine was discontinued but antacids were continued. Day 6 was started with prednisone 60 mg daily. On day 10, renal biopsy Under light microscope, there was obvious infiltration of lymphocytes and plasma cells in the renal interstitium. Immunofluorescence: small in kidneys