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C型肝炎病毒(HCV)是极易发生变异的病毒,已知世界各地分离鉴定的HCV株间碱基序列有很多不同。Okamoto等分析很多HCV株相同性的研究,提出HCV至少分为4型(Ⅰ、Ⅱ、Ⅲ、Ⅳ型〕。Chron公司的Houghton等报告至少可分3组(HCVⅠ、HCVⅡ、HCVⅢ)。此外,Enomoto等也报告从HCV的NS5区域分析可分为4个亚型(PT、K1、K2a、K2b)。Okamoto等的Ⅰ型相当于Houghton等的HCVⅠ、Enomoto等的PT,是Chiron公司最初报告的原型HCV株。Okamoto等的Ⅱ型相当于Houghton等的HCVⅡ、Enomoto等的K1型,为占日本HCV携毒者70～80%的基因型。OKamoto等的Ⅲ型相当于Enomoto等的K2a、ⅠⅣ型为
Hepatitis C virus (HCV) is a virus that is highly susceptible to mutation. It is known that there are many differences in HCV intergenic nucleotide sequences isolated and identified around the world. Okamoto et al. Analyzed many studies on the identity of HCV strains and suggested that HCV should be divided into at least four types (Types I, II, III, and IV). Chron’s Houghton et al. Report can be divided into at least three groups (HCV I, HCV II, HCV III) Enomoto et al. Also report that NS5 region analysis from HCV can be divided into four subtypes (PT, K1, K2a, K2b). Type I of Okamoto et al. Corresponds to HCV I of Houghton et al., PT of Enomoto et al., Originally reported by Chiron Prototype HCV strain Type 2 of Okamoto et al. Corresponds to HCV II of Houghton et al., K1 type of Enomoto et al., And genotype 70 to 80% of HCV co-infected in Japan. Type III ofOKamoto et al. Corresponds to K2a and IV of Enomoto et al. Type is