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  5. Preparation and primary biological evaluation of novel nitrido-188Re complexes/lipiodol

Preparation and primary biological evaluation of novel nitrido-188Re complexes/lipiodol

来源 :核技术（英文版） | 被引量 : 0次 | 上传用户：weistiger
【摘 要】
：
Two new nitrido-188Re complexes were prepared by a modified method in high yield.These complexes were stable in vitro.The biodistribution in normal mice showed
【作 者】
：
WANG Guanquan WEI Hongyuan LUO 
【机 构】
：
Institute of Nuclear Physics and Chemistry
【出 处】
：
核技术（英文版）
【发表日期】
：
2004年期
【关键词】
：
Nitrido TDD derivatives Lipiodol Liver cancer 
【基金项目】
：
Science & Technology Development Foundation of CAEP
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论文部分内容阅读
Two new nitrido-188Re complexes were prepared by a modified method in high yield.These complexes were stable in vitro.The biodistribution in normal mice showed that these nitrido-188Re complexes could accumulate in liver and dissipate quickly from almost all organs.TAE was performed with the use of lipiodol solutions of two complexes to rabbit VX2 liver tumor models.SPECT images showed that the two lipiodol solutions could remain in tumor for about 9 h (188ReN-NEPTDD/lipiodol) and 12 h (188ReN-NEMMPTDD/Iipiodol),respectively.
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