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目的探讨双水平持续正压通气治疗早产儿呼吸窘迫综合征的疗效。方法呼吸窘迫综合征早产儿72例,随机分为观察组和对照组,各36例。对照组行鼻塞式持续气道正压通气治疗,观察组行双水平持续正压通气治疗,对比两组辅助通气、常压氧疗时间,两组动脉血氧饱和度(Sa O2)、动脉血二氧化碳分压(Pa CO2)及动脉血氧分压(Pa O2)水平,并发症发生情况。结果观察组无创呼吸机持续时间为(11.23±13.11)d,长于对照组的(4.11±4.91)d(P<0.05);观察组有创呼吸机持续时间和总常压氧疗时间分别为(2.01±4.73)、(5.64±8.72)d,均短于对照组的(5.88±8.32)、(11.88±14.11)d(P<0.05)。观察组治疗后Sa O2为(94.88±2.34)%、Pa CO2为(42.01±2.31)mm Hg、Pa O2为(62.25±7.65)mm Hg,对照组治疗后Sa O2为(81.17±3.01)%、Pa CO2为(46.87±3.73)mm Hg、Pa O2为(53.01±6.67)mm Hg,治疗后观察组Sa O2、Pa O2水平高于对照组,Pa CO2水平低于对照组,差异均具有统计学意义(P<0.05)。观察组视网膜病变发生率(2.78%)和支气管肺发育不良发生率(8.33%)均低于对照组的(22.22%和33.33%)(P<0.05)。结论双水平持续正压通气治疗早产儿呼吸窘迫综合征可有效减轻氧中毒,减少并发症,值得推广。
Objective To investigate the effect of continuous ambulatory ventilation with double-level on respiratory distress syndrome in preterm infants. Methods 72 cases of respiratory distress syndrome preterm children were randomly divided into observation group and control group, each 36 cases. The patients in the control group received nasal continuous positive airway pressure ventilation, and the observation group received continuous positive airway pressure ventilation. The mean arterial oxygenation time, arterial oxygen saturation (Sa O2), arterial blood The partial pressure of carbon dioxide (PaCO2) and arterial partial pressure of oxygen (PaO2) levels, the incidence of complications. Results The duration of invasive ventilator in the observation group was (11.23 ± 13.11) d, which was longer than that in the control group (4.11 ± 4.91) d (P <0.05). The duration of invasive ventilator and total atmospheric oxygen therapy in the observation group were 2.01 ± 4.73 and 5.64 ± 8.72 d, respectively, which were all shorter than those in the control group (5.88 ± 8.32) and (11.88 ± 14.11) days (P <0.05). Sa O2 was (94.88 ± 2.34)%, Pa CO2 was (42.01 ± 2.31) mm Hg, Pa O2 was (62.25 ± 7.65) mm Hg in the observation group and (81.17 ± 3.01)% in the control group after treatment. PaCO 2 was (46.87 ± 3.73) mm Hg, Pa O 2 was (53.01 ± 6.67) mm Hg. After treatment, the levels of SaO 2 and PaO 2 in the observation group were higher than those in the control group, PaCO 2 level was lower than that in the control group Significance (P <0.05). The incidence of retinopathy (2.78%) and the incidence of bronchopulmonary dysplasia (8.33%) in the observation group were lower than those in the control group (22.22% and 33.33% respectively) (P <0.05). Conclusion Biphasic continuous positive pressure ventilation in the treatment of respiratory distress syndrome in preterm infants can effectively reduce oxygen toxicity and reduce complications and is worth promoting.