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给雄性Wistar系大鼠一次腹腔注射野百合硷50mg/kg,经3周形成了肺动脉高压和右心室肥大。左心室未见明显变化,体循环血压反略有降低。此外,肺湿重增加,提示有肺渗出的病变。还观察了野百合硷的剂量、经过的时间和大鼠初始体重对右室肥大形成的影响。
Male Wistar rats were injected intraperitoneally with monocrotaline 50 mg / kg for 3 weeks to develop pulmonary hypertension and right ventricular hypertrophy. No significant changes in the left ventricle, systemic blood pressure decreased slightly. In addition, increased lung wet weight, suggesting that lung exudate lesions. The dose of lilium base, the elapsed time and the initial weight of rats on the formation of right ventricular hypertrophy were also observed.