目的研究妇女生殖道B群链球菌(GBS)的检出率及药物敏感性分析。方法对温州医科大学附属第一医院5115例妇女生殖道标本进行病原菌培养,重点对检到的B群链球菌进行药物敏感性试验及对该标本相应阴道分泌物进行分析。结果 5115例妇女生殖道标本中共培养B群链球菌180株,检出率为3.52%(180/5115例)。180株B群链球菌对万古霉素、替考拉宁、奎奴/达福普汀、替加环素、氨苄西林、青霉素的敏感率均为100.00%(180/180例),对呋喃妥因的敏感率为92.22%(166/180例),对莫西沙星的敏感率为82.22%(148/180例),对左氧氟沙星的敏感率为81.11%(146/180例),对环丙沙星的敏感率为55.00%(99/180例),对红霉素的敏感率为22.22%(40/180例),对克林霉素的敏感率为10.00%(18/180例),对四环素的敏感率为7.78%(14/180例)。携带B群链球菌的妇女阴道分泌物的常规检测的结果显示,阴道分泌物p H值以p H>4.40为主,为77.78%(140/180例);清洁度以Ⅲ度为主,为54.44%(98/180例)、Ⅳ度为17.78%(32/180例);滴虫为5.56%(10/180例),真菌为12.22%(22/180例),线索细胞为8.89%(16/180例),唾液酸苷酶阳性率为13.33%(24/180例),过氧化氢阳性率为98.89%(178/180例),白细胞酯酶阳性率为95.56%(172/180例)。结论妇女生殖道B群链球菌携带率相对较低,B群链球菌对常用抗菌药物敏感性较高,携带B群链球菌妇女基本上具有阴道炎症反应。 Objective To study the detection rate and drug susceptibility of Streptococcus group B (GST) in the female genital tract. Methods 5115 cases of female reproductive tract specimens from the First Affiliated Hospital of Wenzhou Medical University were tested for pathogenic bacteria. The drug susceptibility tests of the detected group B streptococcus and the corresponding vaginal discharge of the specimens were analyzed. Results Among 5115 female reproductive tract specimens, 180 strains of Streptococcus group B were co-cultured, the detection rate was 3.52% (180/5115 cases). The susceptibilities of 180 strains of Streptococcus group B to vancomycin, teicoplanin, quinuclidine, daptoxicam, tigecycline, ampicillin and penicillin were all 100.00% (180/180) The sensitivity rate was 92.22% (166/180 cases), the sensitivity rate to moxifloxacin was 82.22% (148/180 cases), the sensitivity rate to levofloxacin was 81.11% (146/180 cases), the sensitivity rate to ciprofloxacin The sensitivity rate was 55.00% (99/180), the sensitivity rate to erythromycin was 22.22% (40/180), the sensitivity rate to clindamycin was 10.00% (18/180), the sensitivity to tetracycline The sensitivity rate was 7.78% (14/180 cases). The results of routine tests on vaginal secretions of women carrying group B streptococcus showed that the p H value of vaginal secretions was predominantly p H> 4.40, which was 77.78% (140/180 cases); the degree of cleanliness was mainly Ⅲ degree 54.44% (98/180 cases), Ⅳ degree was 17.78% (32/180 cases), trichomoniasis 5.56% (10/180 cases), fungi 12.22% (22/180 cases) and clue cells 8.89% 16/180), the positive rate of neuraminidase was 13.33% (24/180), the positive rate of hydrogen peroxide was 98.89% (178/180), the positive rate of leukocyte esterase was 95.56% (172/180 cases ). Conclusion The prevalence of Streptococcus group B streptococcal in the reproductive tract of women is relatively low. Group B Streptococcus is more sensitive to commonly used antibiotics, and women carrying group B streptococcal basically have vaginal inflammatory reaction.