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Objective To investigate the correlation of HLA-DR gene with susceptibility and clinical manifestations of sarcoidosis. Method Fifty-five patients with sarcoidosis and 106 normal subjects were investigated by using allele group specific polymerase chain reaction technique （PCR）. Results The gene frequency of HLA-DR5 increased significantly in patients with sarcoidosis （P＜0.01）, but that of HLS-DR7 decreased （P＜0.05）. Gene frequencies of HLA-DR9 and HLA-DR5 increased remarkably in male patients and in patients with stage Ⅰ and stage Ⅱ a, respectively （P＜0.05）. Conclusion HLA-DR gene might contribute to the susceptibility and differently clinical manifestations of sarcoidosis.