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目的:观察多沙唑嗪治疗输尿管下段结石的疗效。方法:50例输尿管下段结石患者随机分为两组,各25例,对照组予常规抗炎、解痉治疗,疼痛时给予双氯酚酸钠缓释片50mg,po;治疗组在对照组基础上加用甲磺酸多沙唑嗪控释片4mg,qd,睡前服。治疗时间不超过14d,其间每周复查B超和腹部平片,记录排石时间和药物不良反应。结果:治疗组排石率72%(18/25),明显高于对照组排石率40%(10/25),差异有统计学意义(P<0.05)。两组患者排石所用时间比较,差异有统计学意义(P<0.01)。治疗中未见药品不良反应。结论:多沙唑嗪可有效提高输尿管下段结石的排出率、排石时间短,安全性好。
Objective: To observe the efficacy of doxazosin in the treatment of lower ureteral calculi. Methods: Fifty patients with lower ureteral calculi were randomly divided into two groups (n = 25 each). The control group was given conventional anti-inflammatory and antispasmodic treatment. When the pain was given, diclofenac sodium sustained release tablets 50 mg and po were given to the treatment group on the basis of the control group On the increase with methanesulfonic acid doxazosin controlled release tablets 4mg, qd, bedtime service. Treatment time does not exceed 14d, during the weekly review of B-and abdominal plain film, record row of stone time and adverse drug reactions. Results: The rate of stone removal in the treatment group was 72% (18/25), which was significantly higher than that in the control group (40%, 10/25). The difference was statistically significant (P <0.05). There was significant difference between the two groups (P <0.01). No adverse drug reactions in the treatment. Conclusion: Doxazosin can effectively improve the lower ureteral stone discharge rate, row of stone time is short, good safety.