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目的:初步探讨血管紧张素转化酶(ACE)基因插入/缺失(I/D)多态性及复方口服避孕药(COC)使用对脑卒中的影响。方法:收集女性脑卒中患者,利用PCR技术和扩增片段长度多态性(AFLP)的方法检测ACE基因多态性。根据高血压的有无将患者分成两组,按病例-病例研究的方法进行探讨。结果:无论是单独考虑服药或是单独考虑携带D型等位基因,其对高血压均没有显著性影响(P>0.05)。但是携带D型等位基因的妇女,如果同时服药15年以上,发生高血压的危险性将有显著性增加(OR=5.71,P=0.03)。结论:携带D型等位基因和长期服用COC(15年以上)可能会增加高血压的发生。提示对妇女服药前进行遗传危险因素筛选和服药时血压监测的必要性。
Objective: To investigate the effect of angiotensin converting enzyme (ACE) gene insertion / deletion (I / D) polymorphism and compound oral contraceptives (COC) on stroke. Methods: The female patients with stroke were recruited. ACE gene polymorphism was detected by PCR and amplified fragment length polymorphism (AFLP). Patients were divided into two groups according to the presence or absence of hypertension, and the case-case study was conducted. Results: No significant effect on hypertension was found in patients taking D-allele alone or alone (P> 0.05). However, women who carry the D allele have a significant increase in the risk of developing hypertension (OR = 5.71, P = 0.03) if taken at the same time for more than 15 years. CONCLUSIONS: Carrying the D-type allele and prolonged use of COC (over 15 years) may increase the occurrence of hypertension. Prompted the women before taking the screening of genetic risk factors and the need for blood pressure monitoring medication.