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在脂多糖(LPS)诱导的细胞信号转导过程中,髓样分化蛋白-2(MD-2)与LPS和Toll样受体4(TLR4)分别结合,发挥桥梁分子的作用,介导TLR4对LPS的识别。LPS是与MD-2结合,而不是TLR4,没有MD-2的参与,细胞也不能发生反应或反应微弱。MD-2可被分泌到血浆中,形成可溶性的MD-2,对只含有TLR4而无MD-2的细胞进行远程调控。表明MD-2在转导内毒素信号中具有重要作用。MD-2具有分子质量小、核酸片段短、便于调控等特点,是极具潜力的新型抗炎靶点。
During LPS-induced cell signal transduction, MD-2 binds to LPS and Toll-like receptor 4 (TLR4) respectively and serves as a bridging molecule that mediates TLR4-dependent LPS recognition. LPS is combined with MD-2, but not TLR4, no MD-2 involved, the cells can not react or weak response. MD-2 can be secreted into the plasma to form soluble MD-2 and to remotely regulate cells containing only TLR4 but not MD-2. This indicates that MD-2 plays an important role in the transduction of endotoxin signals. MD-2 has the characteristics of small molecular weight, short nucleic acid fragments, easy to regulate and so on. It is a potential new anti-inflammatory target.