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目的 探讨抗核小体抗体与系统性红斑狼疮活动度的相关性。方法 采用酶联免疫吸附试验 (ELISA)检测 88例系统性红斑狼疮患者血清中的抗核小体抗体 ,将抗核小体抗体与疾病活动度 (以SLEDAI评价 )、抗双链DNA抗体、补体等指标进行比较。结果 抗核小体抗体在 70例系统性红斑狼疮患者 (79 5 % )中为阳性 ,抗核小体抗体与疾病活动度SLEDAI评分、抗双链DNA抗体、补体C3水平和血沉有相关性。结论 抗核小体抗体在系统性红斑狼疮中敏感性较高 ,是了解狼疮活动度的良好指标
Objective To investigate the correlation between anti-nucleosome antibodies and systemic lupus erythematosus activity. Methods Serum anti-nucleosome antibodies of 88 patients with systemic lupus erythematosus were detected by enzyme-linked immunosorbent assay (ELISA). Anti-nucleosomal antibodies and disease activity (evaluated by SLEDAI), anti-dsDNA antibodies, And other indicators for comparison. Results The anti-nucleosomal antibodies were positive in 70 patients with systemic lupus erythematosus (79.5%). Anti-nucleosomal antibodies were correlated with disease activity SLEDAI score, anti-dsDNA antibody, complement C3 level and erythrocyte sedimentation rate. Conclusion Anti-nucleosome antibodies are highly sensitive in systemic lupus erythematosus and are a good indicator of lupus activity