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目的 研究生物活性玻璃陶瓷（BGC）人工骨植入下颌骨缺损远期的组织学及超微结构变化。方法 对2例因肿瘤行部分下颌骨切除生物活性玻璃陶瓷植入术后8～10年的BGC标本用电子显微镜进行超微结构观察，部分样本脱钙后行HE染色组织学观察，并与植入前的BGC作对照。结果 材料与其外侧的板状骨结合紧密，多数板状骨以钉突形式长入材料中，晶体孔隙间充满了骨样组织；脱钙后组织学观察见大量纤维结缔组织长入材料中，材料中心亦有管状骨长入。结论 BGC复合自体骨植入有良好的骨替代效果，克服其脆性后有较大的临床应用前景。“,”Objective To study the histological changes and ultramicroscopicstructure differences between primary bioactive glass ceramics(BGC) and that implanted in mandible as bone substitute for 8～10 years. Methods Specimens retreved from two patients were obtained and electric scanning microscope and HE staining were employed. Results The new bone fixed tightly with less than 10 μm space at the interface between new bone and BGC,bone tissue extends into the material via pin-like structure or even to the center of the BGC block.Fibrous tissue could penetrate the whole thickness of the BGC(10mm),the space of BGC crystalline fulfilled with bone-like materials. Conclusion BGC and host bone complex implantation result in satisfactory functional and esthetics outcomes,to overcome its fatigue could result in prosperous future.