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高血压是人类心血管合并症中最重要的危险因子之一。血压每升高10mmHg,临床上心血管疾病总发病率亦增加30%左右。冠心病总发生率在高血压者较血压正常者约大3倍。外周血管功能不全的总发生率在高血压者较血压正常者高两倍。本文报道实验性高血压对动脉壁的作用方面所取得的一些进展。对动脉内膜的作用内皮细胞的通透性:短期高血压可使内膜对铁蛋白、胶体铁、辣根过氧化物酶和纤维蛋白等的通透性升高。机理未明。一般认为与内皮细胞缺失或内膜面自发性裸露无
Hypertension is one of the most important risk factors in cardiovascular complications in humans. Blood pressure increased by 10mmHg, the overall incidence of clinically increased cardiovascular disease was also about 30%. The overall incidence of coronary heart disease in hypertensive patients than normal blood pressure about 3 times larger. The overall incidence of peripheral vascular insufficiency is twice as high in those with hypertension as compared to those with normal blood pressure. This article reports some progress made in the effects of experimental hypertension on the arterial wall. Effect on Intima Endothelial Cell Permeability: Short-term hypertension increases endometrial permeability to ferritin, colloidal iron, horseradish peroxidase and fibrin. Mechanism is unknown. Generally considered with endothelial cells missing or spontaneous endometrial exposed no