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白细胞介素-15(IL-15)能激活JAK1、JAK3/STAT3、STAT5和Src家族信号传递途径,诱导记忆性CD4~+、CD8~+和纯真CD8~+T细胞表达早期活化标志CD69,促其增殖。IL-15是诱导Th1细胞、γδT细胞和NK细胞分化发育的重要因子,对Th2细胞发育作用不大。在抗细菌感染早期IL-15发挥第一防线作用。对HIV感染,则以IL-2非依赖方式促进病毒特异性效应CTL的成熟及扩增。IL-15可诱导LAK活性细胞,以CD18粘附分子及穿孔素介导机制溶解自身和(或)异体肿瘤,其治疗指数高于IL-2。此外,IL-15还与多种临床疾病的致病机理相关。
Interleukin-15 (IL-15) activates the JAK1, JAK3 / STAT3, STAT5 and Src family signaling pathways and induces the expression of CD69 +, CD8 +, and CD8 + T cells in early stage of CD8 + T cells Its proliferation. IL-15 is an important factor inducing the differentiation and development of Th1 cells, γδT cells and NK cells, and has little effect on the development of Th2 cells. In the early anti-bacterial infection IL-15 play a first line of defense. For HIV infection, CTL maturation and amplification are promoted in a IL-2-independent manner. IL-15 induces LAK-activated cells to lyse itself and / or allogeneic tumors with CD18 adhesion molecules and perforin-mediated mechanisms with a higher therapeutic index than IL-2. In addition, IL-15 is also associated with the pathogenesis of many clinical diseases.