【目的】研究肺癌患者血浆葡萄糖、丙氨酸浓度与体重减轻的关系。【方法】选取确诊为非小细胞性肺癌的患者,根据体重有无减少分为体重稳定组和体重减轻组,用健康人为正常对照组;调查营养状况、血浆中葡萄糖、丙氨酸的浓度,分析患者血浆葡萄糖、丙氨酸浓度与体重减轻的关系。【结果】被检者食物摄入与发病前无变化,热量、碳水化合物、蛋白质或脂肪的摄入组间无差异,体重减轻组葡萄糖浓度高于体重稳定组患者;体重减轻组肺癌患者血浆丙氨酸浓度低于体重稳定组,(P<0.01)。【结论】体重减轻肺癌患者葡萄糖、丙氨酸代谢发生改变。 【Objective】 To investigate the relationship between plasma glucose, alanine and weight loss in patients with lung cancer. 【Methods】 The patients diagnosed as non-small cell lung cancer were divided into two groups according to whether the body weight was reduced or not. The healthy control group was used to investigate the nutritional status, plasma glucose, alanine concentrations, Analysis of patients with plasma glucose, alanine concentration and weight loss. 【Results】 There was no difference in food intake between the subjects before and after the onset of illness, with no differences in caloric, carbohydrate, protein or fat intakes, glucose concentrations in weight loss group were higher than those in stable weight group, and weight loss group The concentration of amino acid was lower than that of body weight stable group (P <0.01). 【Conclusion】 The glucose and alanine metabolism of lung cancer patients with weight loss change.