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目的:了解某院晚期癌痛患者长期口服吗啡类制剂的有效性及安全性。方法:采用病历回顾性研究方法,分析某院2008年10月～2010年10月门诊晚期癌痛患者信息,统计使用口服吗啡类制剂超过90 d的患者用药数据及止痛效果分值。结果:共有56例患者入选,有18例患者的初始剂量超过了最大剂量的下限25 mg,其中首次应用者8例。患者其止痛剂量最大调整幅度为日剂量15 mg增加到670 mg。在120 mg以下剂量范围内,止痛时间占所有止痛时间的65%。56例患者中,完全缓解1例,明显缓解38例,中度缓解17例。结论:长期应用吗啡口服制剂患者,镇痛效果仍可维持,安全性可控。
Objective: To understand the effectiveness and safety of long-term oral morphine preparations in patients with advanced cancer in a hospital. Methods: A retrospective study of medical records was used to analyze the information of patients with advanced cancer at outpatients from October 2008 to October 2010 in a hospital. The data of drug use and analgesic scores of patients receiving oral morphine for more than 90 days were collected. RESULTS: A total of 56 patients were enrolled, with an initial dose of 18 patients exceeding the maximum limit of 25 mg, of whom 8 were first-time users. The patient’s maximum adjustment for analgesic dose increased from 15 mg daily dose to 670 mg. In the 120 mg dose range, pain relief time accounted for 65% of all painkillers. In 56 patients, complete remission in 1 case, significantly relieved in 38 cases, 17 cases of moderate remission. Conclusion: Long-term use of oral morphine in patients with analgesic effect can still be maintained, safety controllable.