本实验观察了人参茎叶皂甙(GSLS)对雄性大鼠血浆催乳素水平、垂体催乳素细胞超微结构和下丘脑中枢神经递质的影响。结果表明:5～100mg/kg的GSLS可刺激催乳素的释放,剂量加大反而无效;GSLS还可拮抗急性饥饿所致的大鼠垂体催乳素细胞超微结构的损伤;GSLS能分别使大鼠下丘脑中多巴胺和5-羟色胺含量增高和降低。结果表明,GSLS有刺激垂体催乳素分泌的作用,其机制可能与其直接作用于垂体细胞和/或经下丘脑中多巴胺和5-羟色胺含量的变化有关。 In this study, we observed the effect of ginseng stem and leaf saponin (GSLS) on plasma prolactin level, pituitary prolactin cell ultrastructure and hypothalamic neurotransmitter in male rats. The results showed that: GSLS 5 ~ 100mg / kg can stimulate the release of prolactin, the dose increased but not effective; GSLS can also antagonize the acute starvation of rat pituitary prolactin ultrastructural damage; GSLS can rat The hypothalamus dopamine and serotonin levels increased and decreased. The results showed that GSLS could stimulate the secretion of pituitary prolactin, the mechanism may be related to its direct role in the pituitary cells and / or hypothalamus dopamine and 5-hydroxytryptamine content changes.