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目的探讨洛伐他汀对血脂正常的高血压患者的血压及左室重构的影响。方法 57例血脂正常的高血压患者,随机分为治疗组和对照组,治疗组25例,对照组25例。两组均给予缬沙坦80mg/d口服,氢氯噻嗪12.5mg/d口服,治疗组加用洛伐他汀20mg/d,每晚一次口服,疗程6个月。治疗前后分别测量血压及左室质量指数。结果两组治疗前后血压及左室质量指数均明显下降,(P<0.01),治疗组较对照组下降更明显,(P<0.05)。结论洛伐他汀对缬沙坦具有协同降压作用,且能明显降低左室质量指数。
Objective To investigate the effect of lovastatin on blood pressure and left ventricular remodeling in patients with normal blood lipids. Methods Fifty-seven patients with hyperlipidemia were randomly divided into treatment group and control group, with 25 cases in the treatment group and 25 cases in the control group. Both groups were given oral valsartan 80mg / d, hydrochlorothiazide 12.5mg / d orally, the treatment group plus lovastatin 20mg / d, once every night oral treatment for 6 months. Before and after treatment were measured blood pressure and left ventricular mass index. Results Before and after treatment, blood pressure and left ventricular mass index decreased significantly (P <0.01), and the treatment group decreased more significantly than the control group (P <0.05). Conclusion Lovastatin has a synergistic antihypertensive effect on valsartan, and can significantly reduce the left ventricular mass index.