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目的研究肺癌、结肠癌和直肠癌患者血清瘦素(Leptin)的表达变化,探讨其与患者预后的关系。方法采集肺癌、结肠癌、直肠癌患者及正常对照者的血清样品,采用相应试剂盒检测血清Leptin、癌胚抗原的水平,采用全自动生化分析仪检测反映脏器功能、代谢功能的相关生化指标变化。结果与正常对照者相比,三种肿瘤患者血清Leptin显著升高,癌胚抗原、脏器功能指标和代谢指标均有不同程度变化。结论Leptin可能作为评价恶性肿瘤患者状况的新指标。
Objective To study the expression of Leptin in patients with lung cancer, colon cancer and rectal cancer and to explore its relationship with the prognosis of patients. Methods Serum samples from patients with lung cancer, colon cancer, rectal cancer and normal controls were collected. Serum levels of Leptin and carcinoembryonic antigen were detected with corresponding kits. The biochemical indicators reflecting organ function and metabolism were detected by automatic biochemical analyzer Variety. Results Compared with the normal controls, the serum Leptin levels of the three tumor patients were significantly increased, and the carcinoembryonic antigen, organ function indexes and metabolic indexes all had different degrees of change. Conclusion Leptin may be used as a new indicator to evaluate the status of patients with malignant tumors.