作者试图阐明急性高血糖对山梨糖醇值的影响,通过口服葡萄糖负荷试验观察山梨糖醇值的变化。 对象与方法:对象为糖尿病患者56例、糖耐量异常(IGT)27例、非糖尿病者18例,平均年龄分别为55.4、48.7、41.9岁。其中IDDM3例、NIDDM53例,平均患病8年。饮食疗法组24例,口服降血糖药组16例,注射胰岛素组16例。 受试病例于早晨空腹口服葡萄糖进行负荷试验,于负荷前30、60、90、120、180分钟采血,分别用葡萄糖一氧化酶法、放免法(RIA)、酶测定法测定血糖、血中胰岛素浓度(IRI)、红细胞山梨糖醇。按日本糖尿病学会委员会的推荐方案,根 The authors attempted to elucidate the effects of acute hyperglycemia on sorbitol values ​​and to observe the changes in sorbitol values ​​through an oral glucose load test. Subjects and Methods: The subjects were 56 cases of diabetic patients, 27 cases of impaired glucose tolerance (IGT) and 18 cases of non-diabetic patients. The average age were 55.4, 48.7 and 41.9 years respectively. Including IDDM3 cases, NIDDM53 cases, the average sick for 8 years. Diet therapy group 24 cases, oral hypoglycemic group 16 cases, insulin group 16 cases. The test cases were orally administered with glucose in the fasting morning, and the blood samples were taken at 30, 60, 90, 120 and 180 minutes before the load. Glucose and oxidase, radioimmunoassay (RIA) Concentration (IRI), erythrocyte sorbitol. According to the Japanese Diabetes Association recommended program, root