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目的探讨孕中期经超声诊断的孤立性股骨短小(ISF)胎儿的临床预后。方法回顾性分析于我院行产前超声检查诊断为ISF胎儿67例,并进行产后追踪随访,通过与正常对照组比较,评价ISF胎儿的预后情况。结果产前超声诊断并活产,产后资料完整的ISF胎儿67例,同时纳入对照组200例。ISF组患儿出生体质量低于对照组(2 787.2g vs 3 124.5g,P<0.01),其小于胎龄儿、低出生体质量儿发生概率(分别为17.9%vs 7.0%及19.4%vs 8.0%,P<0.05)、早产率(17.9%vs 9.0%,P<0.05)及新生儿重症监护室住院率(20.9%vs 7.5%,P<0.05)均高于对照组。结论孕中期发现的孤立性股骨短小胎儿出生后发生小于胎龄儿、低出生体质量儿的风险增高,提高对该疾病的认识为产前咨询及孕期管理具有一定的临床意义。
Objective To investigate the clinical prognosis of isolated femoral short (ISF) fetuses diagnosed by the second trimester of pregnancy. Methods Retrospective analysis in our hospital prenatal ultrasound diagnosis of ISF fetus in 67 cases, and follow-up postpartum follow-up, compared with the normal control group to evaluate the prognosis of ISF fetus. Results 67 cases of ISF fetuses with complete prenatal diagnosis and live birth and 200 cases of prenatal ultrasound were included in the control group. The birth weight of children with ISF was lower than that of the control group (2 787.2 g vs 3 124.5 g, P <0.01), which was less than that of gestational age children (17.9% vs 7.0% and 19.4% vs 8.0%, P <0.05), preterm birth rate (17.9% vs 9.0%, P <0.05) and neonatal intensive care unit hospitalization rate (20.9% vs 7.5%, P <0.05) were significantly higher than those in the control group. Conclusion The incidence of isolated femoral short fetuses born in the second trimester is higher than that of children born with low birth weight, and the risk of low birth weight children is increased. To improve understanding of the disease is of clinical significance for prenatal consultation and pregnancy management.