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肝纤维化是由肝脏在各种慢性肝损伤条件下的损伤修复反应造成,以细胞外基质过度沉积为主要特征.许多证据表明NADPH氧化酶(nicotinamide adenine dinucleotide phosphate oxidase,NOX)及其产生的活性氧簇(reactive oxygen species,ROS)引起的氧化应激在肝纤维化中起关键作用.NOX是一个多亚基复合体,在肝脏中,吞噬细胞型和非吞噬细胞型的NOX均有功能性表达,并对引起肝纤维化的主要细胞-肝星状细胞(hepatic stellate cells,HSCs)均具有明显的促纤维化作用.本文就NOX家族在肝纤维化的发生、发展中的作用的近几年研究进展做一综述.
Liver fibrosis is caused by the damage-repair reaction of the liver under various conditions of chronic liver injury, with extracellular matrix over-deposition as the main feature.Many evidences suggest that nicotinamide adenine dinucleotide phosphate oxidase (NOX) and its activity Oxidative stress caused by reactive oxygen species (ROS) plays a key role in hepatic fibrosis.NOX is a multisubunit complex in which both phagocytic and non-phagocytic NOX are functional Expression and hepatic fibrosis of the main cells - hepatic stellate cells (hepatic stellate cells, HSCs) have significant role in promoting fibrosis.In this paper, the NOX family in the occurrence and development of liver fibrosis in recent The research progress of the year is reviewed.